Peptide Hormone PhIP-Seq Services

Transform Your Peptide Hormone Research

As part of our HuScan services, we are now offering our Peptide Hormone PhIP-Seq library services. Discover, quantify, and analyze peptide hormone interactions like never before.

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Advanced Services for Detecting Hormone-specific Autoantibodies

Unlock the Hidden Role of Hormone-targeting Autoantibodies in Health and Disease

The endocrine system controls critical physiological processes through peptide hormones, but emerging research reveals a crucial missing piece: circulating autoantibodies that bind directly to these hormones. Our innovative Peptide Hormone PhIP-Seq service provides the most comprehensive platform available for identifying these hormone-specific autoantibodies and their role in disease.

PhIP-Seq Methods and Analysis

HuScan PhIP-Seq enables simultaneous epitope-level autoantibody profiling against an entire human proteome.

PhIP-Seq Methods and Analysis Figure


Peptide Hormone PhIP-Seq detects antibodies against 6,520 unique peptides against 356 targets

Revolutionary PhIP-Seq Technology

Our Peptide Hormone PhIP-Seq service combines the power of phage display with next-generation sequencing to deliver unprecedented insights into hormone-targeting autoantibodies.

Due to the critical nature of these peptides and variations in phage display structure which might inhibit detection of an antibody response, each peptide hormone was displayed redundantly in multiple windowed contexts. Short hormones were displayed to the left, center, right, or repeated across the 34-mer peptide display window. Each version was displayed 5-times, providing abundant experimental redundancy for real detected reactions. An example of this for an insulin peptide is shown in the table below.

Peptide Hormone PhIP-Seq Library Design Strategy

An example of this for an insulin peptide is shown here.

Human peptide hormone PhIP-Seq library design strategy

Comprehensive Coverage and Unmatched Expertise

6,520 unique peptides

representing 356 hormone entries

290 human peptide hormones

plus 66 pharmaceutical preparations

Multiple display contexts

with 5-fold redundancy for maximum sensitivity

Epitope-level resolution

for precise antibody mapping

Proven validation

with commercial insulin antibodies and human serum samples

Why Hormone-targeting Autoantibodies Matter

Traditional approaches to hormonal disorders have focused on genetic, metabolic, and environmental factors. However, mounting evidence shows that autoantibodies reactive to peptide hormones play a significant role in:

Metabolic Disorders

Autoantibodies against appetite-regulating hormones linked to obesity, anorexia nervosa, and bulimia

Endocrine Dysfunction

Thyroid-targeting antibodies in Hashimoto's thyroiditis and Graves' disease

Neuropsychiatric Conditions

ACTH-reactive antibodies associated with aggression and conduct disorders

Growth and Development

IGF2 autoantibodies implicated in growth disorders and cancer

Reproductive Health

Autoantibodies targeting reproductive hormones like FSH, LH, and hCG contributing to infertility, polycystic ovary syndrome, and pregnancy complications

Why Choose CDI Labs Canada?

As leaders in high-throughput serological screening, CDI Labs Canada combines cutting-edge technology with deep scientific expertise.

Our Peptide Hormone PhIP-Seq service represents the next generation of autoantibody detection, providing researchers with the tools needed to understand the complex interplay between hormones, immunity, and disease. Whether you're investigating metabolic disorders, autoimmune diseases, or exploring novel therapeutic targets, our hormone-focused PhIP-Seq platform delivers the comprehensive, high-resolution data you need to advance your research.

Unmatched Sensitivity

Our hormone-focused library provides superior detection compared to traditional one-by-one assays, with built-in redundancy ensuring reliable results.

Epitope-level Resolution

Precise mapping of antibody binding sites enables deeper understanding of autoantibody function and cross-reactivity patterns.

Proven Validation

Extensively validated with commercial insulin antibodies and human serum samples, demonstrating robust performance across diverse sample types.

Expert Analysis

Our team of scientists provides comprehensive data interpretation and supports your research goals with cutting-edge bioinformatics analysis.

Technical Excellence

Peptide Hormone PhIP-Seq services is integrated with HuScan® PhIP-Seq for proteome-wide analysis and is scalable for large cohort studies.