HuScan® Human Proteome PhIP-Seq

Entire Human Proteome in a Single Tube Assay

HuScan® PhIP-Seq is composed of an entire normal human proteome as defined by the NCBI RefSeq database.

REQUEST INFO

HuScan® PhIP-Seq Overview

Phage ImmunoPrecipitation Sequencing (PhIP-Seq) is a powerful method of multiplexed analysis that combines high-throughput DNA sequencing with next-generation proteomics

PhIP-Seq allows researchers to determine what antibodies were created by an individual’s unique history of immune exposures. PhIP-Seq is the highest-coverage antigen-specific assay yet developed, able to detect antibodies versus virtually any antigen via overlapping long peptides. HuScan® enables simultaneous epitope-level autoantibody profiling versus an entire NCBI human proteome (48,921 proteins and isoforms) via phage-display and immunoprecipitation sequencing.

HuScan Overview

HuScan® PhIP-Seq Advantages

Empowering researchers to decode the antibodies shaped by an individual’s unique history of immune exposures

Ultimate Coverage

Detect antibodies targeting virtually any antigen using overlapping long peptides

Total Proteome Profiling

Dive deep into epitope-level insights across the entire RefSeq human proteome

Innovative Technology

Powered by state-of-the-art Phage ImmunoPrecipitation Sequencing for unmatched precision

Transformative Results

Advance autoimmune research, identify biomarkers, and map immune exposure histories

Unparalleled Coverage

Contains over 48,000+ proteins and isoforms, covering over 730,000+ unique peptide sequences

HuScan Technology Overview

What Our Customers Are Saying

"This (VirScan) assay, which uses phage display immunoprecipitation and sequencing, is a sensitive and focused high-comprehensive approach that enables thorough serological profiling of antiviral antibodies in humans and, consequently, the identification of viral exposure throughout the human virome."

Faculty of MedicineResearch Institution (as mentioned in "Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8+ T cells in patients with advanced NSCLC" - Science Advances - November 2023)

What Our Customers Are Saying

"We elected to use the HuProt Microarray because it is an extensive platform that contains over 21,000 unique, individually purified full-length human proteins and protein isoforms in duplicate, covering more than 81% of the proteome."

OncologistSchool of Medicine Research (as mentioned in "Baseline Serum Autoantibody Signatures Predict Recurrence and Toxicity in Melanoma Patients Receiving Adjuvant Immune Checkpoint Blockade" - AACR Clinical Caner Research - September 2022)

What Our Customers Are Saying

"By using (HuProt) protein arrays, we were able to evaluate a broader range of antigens compared to previous investigations."

Senior ScientistBiotech Research (poster presentation at the San Antonio Breast Cancer Symposium 2023)

pdf iconContent

ZIP | 20.10 MB

HuScan PhIP-Seq Content

An entire NCBI human proteome is included in HuScan™ autoantibody testing. ZIP file containing .csv...

VIEW | DOWNLOAD

pdf iconPublication

HuScan: Epitope-level profiling in children with mitochondrial disease reveals limitations in the...

Immunometabolic studies in mice have suggested the importance of oxidative phosphorylation (OXPHOS) in humoral immunity. However, there are important distinctions between murine and human...

VIEW | DOWNLOAD

pdf iconPublication

Characterizing Cancer’s Dark Matter, Short-lived Proteins, and Defective Ribosomal Products, Presented...

Short-lived proteins (SLiPs), defective ribosomal products (DRiPs), and Cancer’s dark matter/non-canonical peptides (NCP) are unstable and rapidly degraded, loaded onto MHC and represent a...

VIEW | DOWNLOAD

pdf iconTechnology

Overview of HuScan® Human Proteome Phage Display

This video / animation is a short overview of the CDI Labs Canada HuScan® Human Proteome Phage Display product and...

VIEW | DOWNLOAD

pdf iconTechnology

Overview of Autoantibody Seromics

This video / animation is a short overview of CDI Labs Autoantibody...

VIEW | DOWNLOAD