VirScan® Viral Proteome PhIP-Seq

The Proteomes of Most Vertebrate Viruses in a Single Assay

VirScan®, an application of Phage ImmunoPrecipitation Sequencing (PhIP-Seq), is composed of the proteomes of most vertebrate viruses.

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Viral Exposure Profiling and Pathogen Surveillance

Phage ImmunoPrecipitation Sequencing (PhIP-Seq) is a powerful method of multiplexed analysis that combines DNA high-throughput sequencing with next-generation proteomics

VirScan allows researchers to determine what antibodies were created by an individual’s unique history of viral exposures. PhIP-Seq is the highest-coverage antigen-specific assay yet developed, able to detect antibodies versus virtually any antigen via overlapping long peptides. VirScan enables simultaneous epitope-level autoantibody profiling versus most vertebrate viruses.

VirScan Overview Figure

VirScan® PhIP-Seq Advantages

Enabling researcher to uncover both individual and population-level histories of viral infections

 

Viral Exposure Profiling and Pathogen Surveillance

Explore the connection between viral exposure and chronic disease

Identify Key Triggers that Contribute to Disease

Gain deeper insights to host-pathogen interactions and immune system's response to viral challenges

Identify and Investigate Instances of Molecular Mimicry

Identify events of molecular mimicry to better understand autoimmune reactions

Detect Antibodies Against Over 68,000+ Viral Proteins

Gain deeper insights for autoimmune diseases, neurological disorders, and cancer

Discover How Viruses May Influence Disease

Discover new epidemiological patterns and the dynamics of infectious disease

VirScan Technology Overview

Data and technology validated by scientists

"This (VirScan) assay, which uses phage display immunoprecipitation and sequencing, is a sensitive and focused high-comprehensive approach that enables thorough serological profiling of antiviral antibodies in humans and, consequently, the identification of viral exposure throughout the human virome."

Faculty of MedicineResearch Institution (as mentioned in "Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8+ T cells in patients with advanced NSCLC" - Science Advances - November 2023)

Data and technology validated by scientists

"We elected to use the HuProt Microarray because it is an extensive platform that contains over 21,000 unique, individually purified full-length human proteins and protein isoforms in duplicate, covering more than 81% of the proteome."

OncologistSchool of Medicine Research (as mentioned in "Baseline Serum Autoantibody Signatures Predict Recurrence and Toxicity in Melanoma Patients Receiving Adjuvant Immune Checkpoint Blockade" - AACR Clinical Caner Research - September 2022)

Data and technology validated by scientists

"By using (HuProt) protein arrays, we were able to evaluate a broader range of antigens compared to previous investigations."

Senior ScientistBiotech Research (poster presentation at the San Antonio Breast Cancer Symposium 2023)

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ZIP | 23.81 MB

VirScan PhIP-Seq Content

Proteomes of all vertebrate viruses are included for VirScan™ autoantibody testing. ZIP file containing .csv...

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VirScan: Human virome profiling identified CMV as the major viral driver of a high accumulation of...

Circulating senescent CD8+ T (T8sen) cells are characterized by a lack of proliferative capacities but retain cytotoxic activity and have been associated to resistance to immunotherapy in...

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Primary oxidative phosphorylation defects lead to perturbations in the human B cell...

The majority of studies on oxidative phosphorylation in immune cells have been performed in mouse models, necessitating human translation. To understand the impact of oxidative phosphorylation...

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Reduced anti-viral IgG repertoire in HIV-exposed but uninfected infants compared to HIV-unexposed...

Infants who are HIV exposed but uninfected (iHEU) have higher risk of viral infections compared to infants who are HIV unexposed (iHUU). We explored the effect of intrauterine HIV exposure on the...

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pdf iconTechnology

Overview of VirScan® Viral Proteome Phage Display

This video / animation is a short overview of the CDI Labs Canada VirScan® Viral Proteome Phage Display product and...

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pdf iconTechnology

Overview of Autoantibody Seromics

This video / animation is a short overview of CDI Labs Autoantibody...

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